Symposium Speaker: Marylyn D. Ritchie, PhD, MS

Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University.  Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic.  Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases.  Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease.  Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research.  Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years.  Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014).  Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.

Recent Publications

  1. Powers, J, Wachtel, H, Trujillo, E, Desai, H, Hausler, R, Conway, L, Wubbenhorst, B, Penn Medicine BioBank, Regeneron Genetics Center, Domchek, SM et al.. Multi-ethnic heterozygote frequencies of cancer susceptibility genes to inform counseling of reproductive risk. Genet Med 2024; : 101246. PubMed PMID:39570271 .
  2. Abramowitz, SA, Boulier, K, Keat, K, Cardone, KM, Shivakumar, M, DePaolo, J, Judy, R, Bermudez, F, Mimouni, N, Neylan, C et al.. Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores. JAMA 2024; : . PubMed PMID:39549270 PubMed Central PMC11569413.
  3. Park, J, Levin, MG, Zhang, D, Reza, N, Mead, JO, Carruth, ED, Kelly, MA, Winters, A, Kripke, CM, Judy, RL et al.. Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3. JAMA Cardiol 2024; : . PubMed PMID:39535783 PubMed Central PMC11561727.
  4. Dunn, ME, Kithcart, A, Kim, JH, Ho, AJ, Franklin, MC, Romero Hernandez, A, de Hoon, J, Botermans, W, Meyer, J, Jin, X et al.. Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone. Nature 2024; 633 (8030): 654-661. PubMed PMID:39261724 PubMed Central PMC11410649.
  5. Pividori, M, Ritchie, MD, Milone, DH, Greene, CS. An efficient, not-only-linear correlation coefficient based on clustering. Cell Syst 2024; 15 (9): 854-868.e3. PubMed PMID:39243756 .
  6. Williams, AT, Shrine, N, Naghra-van Gijzel, H, Betts, JC, Chen, J, Hessel, EM, John, C, Packer, R, Reeve, NF, Yeo, AJ et al.. Genome-wide association study of susceptibility to hospitalised respiratory infections. Wellcome Open Res 2021; 6 : 290. PubMed PMID:39220670 PubMed Central PMC11362726.
  7. Zhang, DY, Levin, MG, Duda, JT, Landry, LG, Witschey, WR, Damrauer, SM, Ritchie, MD, Rader, DJ. Protein-truncating variant in APOL3 increases chronic kidney disease risk in epistasis with APOL1 risk alleles. JCI Insight 2024; 9 (19): . PubMed PMID:39163132 PubMed Central PMC11466179.
  8. Raper, AC, Weathers, BL, Drivas, TG, Ellis, CA, Kripke, CM, Oyer, RA, Owens, AT, Verma, A, Wileyto, PE, Wollack, CC et al.. Protocol for a type 3 hybrid implementation cluster randomized clinical trial to evaluate the effect of patient and clinician nudges to advance the use of genomic medicine across a diverse health system. Implement Sci 2024; 19 (1): 61. PubMed PMID:39160614 PubMed Central PMC11331805.
  9. Moore, A, Venkatesh, R, Levin, MG, Damrauer, SM, Reza, N, Cappola, TP, Ritchie, MD. Connecting intermediate phenotypes to disease using multi-omics in heart failure. medRxiv 2024; : . PubMed PMID:39148828 PubMed Central PMC11326335.
  10. Abramowitz, SA, Boulier, K, Keat, K, Cardone, KM, Shivakumar, M, DePaolo, J, Judy, R, Kim, D, Rader, DJ, Ritchie, MD et al.. Population Performance and Individual Agreement of Coronary Artery Disease Polygenic Risk Scores. medRxiv 2024; : . PubMed PMID:39108513 PubMed Central PMC11302700.
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Dr. Ritchie on Twitter

Dr. Ritchie on Twitter

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The Ritchie Lab Website

Curriculum vitae