Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.
Recent Publications
- Tayran, H, Yilmaz, E, Bhattarai, P, Min, Y, Wang, X, Ma, Y, Wang, N, Jeong, I, Nelson, N, Kassara, N et al.. ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. Cell Genom 2024; : 100642. PubMed PMID:39216475 .
- Ma, Y, Reyes-Dumeyer, D, Piriz, A, Recio, P, Mejia, DR, Medrano, M, Lantigua, RA, Vonsattel, JPG, Tosto, G, Teich, AF et al.. Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Acta Neuropathol 2024; 148 (1): 27. PubMed PMID:39177846 PubMed Central PMC11343944.
- Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabali, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption. medRxiv 2024; : . PubMed PMID:39148832 PubMed Central PMC11326357.
- Carter, RC, Yang, Z, Akkaya-Hocagil, T, Jacobson, SW, Jacobson, JL, Dodge, NC, Hoyme, HE, Zeisel, SH, Meintjes, EM, Kizil, C et al.. Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in a South African population. Gene 2024; 931 : 148854. PubMed PMID:39147113 .
- Cheng, PL, Wang, H, Dombroski, BA, Farrell, JJ, Horng, I, Chung, T, Tosto, G, Kunkle, BW, Bush, WS, Vardarajan, B et al.. A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD). medRxiv 2024; : . PubMed PMID:39108532 PubMed Central PMC11302603.
- Volosov, V, Bevilacqua, S, Anoldo, L, Tosto, G, Fontana, E, Russo, AL, Fiegna, C, Sangiorgi, E, Tallarico, AN. Positive Bias Temperature Instability in SiC-Based Power MOSFETs. Micromachines (Basel) 2024; 15 (7): . PubMed PMID:39064382 PubMed Central PMC11279283.
- Carter, RC, Yang, Z, Akkaya-Hocagil, T, Jacobson, SW, Jacobson, JL, Dodge, NC, Hoyme, HE, Zeisel, SH, Meintjes, EM, Kizil, C et al.. Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in the South African Cape Coloured population. medRxiv 2024; : . PubMed PMID:38633769 PubMed Central PMC11023663.
- Ma, Y, Reyes-Dumeyer, D, Piriz, A, Recio, P, Mejia, DR, Medrano, M, Lantigua, RA, Vonsattel, JPG, Tosto, G, Teich, AF et al.. Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups. medRxiv 2024; : . PubMed PMID:38405911 PubMed Central PMC10889011.
- Xicota, L, Cosentino, S, Vardarajan, B, Mayeux, R, Perls, TT, Andersen, SL, Zmuda, JM, Thyagarajan, B, Yashin, A, Wojczynski, MK et al.. Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement 2024; 20 (4): 2670-2679. PubMed PMID:38380866 PubMed Central PMC11032545.
- Leung, YY, Naj, AC, Chou, YF, Valladares, O, Schmidt, M, Hamilton-Nelson, K, Wheeler, N, Lin, H, Gangadharan, P, Qu, L et al.. Human whole-exome genotype data for Alzheimer's disease. Nat Commun 2024; 15 (1): 684. PubMed PMID:38263370 PubMed Central PMC10805795.
