Dr. Thornton is Associate Professor of Biostatistics at the University of Washington (UW) and an Affiliate Investigator at the Fred Hutchinson Cancer Research Center. Dr. Thornton's research involves the development and application of statistical methods for the analysis of large-scale genomic data for the identification of genetic variants that influence complex diseases and quantitative traits. Currently, Dr. Thornton's collaborative research is largely focused on using statistical methods to identify novel genetic variants for complex traits in ancestrally diverse populations, including underrepresented minority populations in the U.S., including African Americans, Latinos, and American Indian and Alaska Native (AI/AN) populations. Dr. Thornton currently serves as a lead statistician and co-investigator for Hispanic Community Health Study (HCHS)/Study of Latinos (SOL), and this cohort was recently included in the multi-cohort Population Architecture using Genomics and Epidemiology (PAGE) II study.
Recent Publications
- Grinde, KE, Browning, BL, Reiner, AP, Thornton, TA, Browning, SR. Adjusting for principal components can induce collider bias in genome-wide association studies. PLoS Genet 2024; 20 (12): e1011242. PubMed PMID:39680601 .
- Kullo, IJ, Conomos, MP, Nelson, SC, Adebamowo, SN, Choudhury, A, Conti, D, Fullerton, SM, Gogarten, SM, Heavner, B, Hornsby, WE et al.. The PRIMED Consortium: Reducing disparities in polygenic risk assessment. Am J Hum Genet 2024; 111 (12): 2594-2606. PubMed PMID:39561770 PubMed Central PMC11639095.
- Ziyatdinov, A, Mbatchou, J, Marcketta, A, Backman, J, Gaynor, S, Zou, Y, Joseph, T, Geraghty, B, Herman, J, Watanabe, K et al.. Joint testing of rare variant burden scores using non-negative least squares. Am J Hum Genet 2024; 111 (10): 2139-2149. PubMed PMID:39366334 PubMed Central PMC11480795.
- Gaynor, SM, Joseph, T, Bai, X, Zou, Y, Boutkov, B, Maxwell, EK, Delaneau, O, Hofmeister, RJ, Krasheninina, O, Balasubramanian, S et al.. Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank. Nat Genet 2024; 56 (11): 2345-2351. PubMed PMID:39322778 PubMed Central PMC11549045.
- Rodriguez-Flores, JL, Khalid, S, Parikshak, N, Rasheed, A, Ye, B, Kapoor, M, Backman, J, Sepehrband, F, Gioia, SAD, Gelfman, S et al.. NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke. Nat Commun 2024; 15 (1): 8029. PubMed PMID:39271666 PubMed Central PMC11399414.
- Horimoto, ARVR, Sun, Q, Lash, JP, Daviglus, ML, Cai, J, Haack, K, Cole, SA, Thornton, TA, Browning, SR, Franceschini, N et al.. Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin. Circ Genom Precis Med 2024; 17 (4): e004314. PubMed PMID:38950085 PubMed Central PMC11394365.
- Vad, OB, Monfort, LM, Paludan-Müller, C, Kahnert, K, Diederichsen, SZ, Andreasen, L, Lotta, LA, Nielsen, JB, Lundby, A, Svendsen, JH et al.. Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk. JAMA Cardiol 2024; 9 (8): 732-740. PubMed PMID:38922602 PubMed Central PMC11209175.
- Sun, KY, Bai, X, Chen, S, Bao, S, Zhang, C, Kapoor, M, Backman, J, Joseph, T, Maxwell, E, Mitra, G et al.. A deep catalogue of protein-coding variation in 983,578 individuals. Nature 2024; 631 (8021): 583-592. PubMed PMID:38768635 PubMed Central PMC11254753.
- Grinde, KE, Browning, BL, Reiner, AP, Thornton, TA, Browning, SR. Adjusting for principal components can induce spurious associations in genome-wide association studies in admixed populations. bioRxiv 2024; : . PubMed PMID:38617337 PubMed Central PMC11014513.
- Ziyatdinov, A, Torres, J, Alegre-Díaz, J, Backman, J, Mbatchou, J, Turner, M, Gaynor, SM, Joseph, T, Zou, Y, Liu, D et al.. Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City. Nature 2024; 626 (8001): E18. PubMed PMID:38332034 PubMed Central PMC10901729.
