JONATHAN HAINES, PHD
Director
Jonathan Haines, PhD, is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Population and Quantitative Health Sciences, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics. He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci. His interests are in adapting and applying statistical computational methods to biomedical big data.
Recent Publications
- Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2024; : . PubMed PMID:39379761 .
- Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2. Alzheimers Dement 2024; : . PubMed PMID:39376159 .
- Grunin, M, Igo, RP Jr, Song, YE, Blanton, SH, Pericak-Vance, MA, Haines, JL, International Age-related Macular Degeneration Genomics Consortium. Identifying X-chromosome variants associated with age-related macular degeneration. Hum Mol Genet 2024; : . PubMed PMID:39324238 .
- Gunasekaran, TI, Reyes-Dumeyer, D, Faber, KM, Goate, A, Boeve, B, Cruchaga, C, Pericak-Vance, M, Haines, JL, Rosenberg, R, Tsuang, D et al.. Missense and loss-of-function variants at GWAS loci in familial Alzheimer's disease. Alzheimers Dement 2024; : . PubMed PMID:39233587 .
- Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabali, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption. medRxiv 2024; : . PubMed PMID:39148832 PubMed Central PMC11326357.
- Ray, NR, Kunkle, BW, Hamilton-Nelson, K, Kurup, JT, Rajabli, F, Qiao, M, Vardarajan, BN, Cosacak, MI, Kizil, C, Jean-Francois, M et al.. Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry. Alzheimers Dement 2024; 20 (8): 5247-5261. PubMed PMID:38958117 PubMed Central PMC11350055.
- Zhu, C, Tong, T, Farrell, JJ, Martin, ER, Bush, WS, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Haines, JL, Lunetta, KL et al.. MitoH3: Mitochondrial Haplogroup and Homoplasmic/Heteroplasmic Variant Calling Pipeline for Alzheimer's Disease Sequencing Project. J Alzheimers Dis Rep 2024; 8 (1): 575-587. PubMed PMID:38746629 PubMed Central PMC11091720.
- Griswold, AJ, Rajabli, F, Gu, T, Arvizu, J, Golightly, CG, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Mena, PR et al.. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv 2024; : . PubMed PMID:38645114 PubMed Central PMC11030471.
- Verma, A, Nittala, MG, Corradetti, G, Nassisi, M, Velaga, SB, He, Y, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR et al.. Longitudinal Evaluation of the Distribution of Intraretinal Hyper-Reflective Foci in Eyes with Intermediate Age-Related Macular Degeneration. Curr Eye Res 2024; : 1-7. PubMed PMID:38639042 .
- Cukier, HN, Simon, SA, Tang, E, Golightly, CG, Laverde-Paz, MJ, Adams, LD, Starks, TD, Vance, JM, Cuccaro, ML, Haines, JL et al.. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem Cell Res 2024; 76 : 103364. PubMed PMID:38422817 .