JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Gorman, BR, Voloudakis, G, Igo, RP Jr, Kinzy, T, Halladay, CW, Bigdeli, TB, Zeng, B, Venkatesh, S, Cooke Bailey, JN, Crawford, DC et al.. Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nat Genet 2024; 56 (12): 2659-2671. PubMed PMID:39623103 .
  2. Bertholim-Nasciben, L, Nuytemans, K, Van Booven, D, Rajabli, F, Moura, S, Ramirez, AM, Dykxhoorn, DM, Wang, L, Scott, WK, Davis, DA et al.. African origin haplotype protective for Alzheimer's disease in APOEε4 carriers: exploring potential mechanisms. bioRxiv 2024; : . PubMed PMID:39484566 PubMed Central PMC11527192.
  3. Cruz-González, S, Gu, E, Gomez, L, Mews, M, Vance, JM, Cuccaro, ML, Cornejo-Olivas, MR, Feliciano-Astacio, BE, Byrd, GS, Haines, JL et al.. Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals. bioRxiv 2024; : . PubMed PMID:39464059 PubMed Central PMC11507840.
  4. Tong, T, Zhu, C, Farrell, JJ, Khurshid, Z, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Neuroimaging Initiative, Martin, ER, Pericak-Vance, MA, Wang, LS, Bush, WS, Schellenberg, GD et al.. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther 2024; 16 (1): 234. PubMed PMID:39444005 PubMed Central PMC11515778.
  5. Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement 2024; : . PubMed PMID:39428839 .
  6. Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2024; 56 (11): 2407-2421. PubMed PMID:39379761 PubMed Central PMC11549054.
  7. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2. Alzheimers Dement 2024; 20 (11): 7453-7464. PubMed PMID:39376159 PubMed Central PMC11567819.
  8. Grunin, M, Igo, RP Jr, Song, YE, Blanton, SH, Pericak-Vance, MA, Haines, JL, International Age-related Macular Degeneration Genomics Consortium. Identifying X-chromosome variants associated with age-related macular degeneration. Hum Mol Genet 2024; 33 (24): 2085-2093. PubMed PMID:39324238 PubMed Central PMC11630753.
  9. Gunasekaran, TI, Reyes-Dumeyer, D, Faber, KM, Goate, A, Boeve, B, Cruchaga, C, Pericak-Vance, M, Haines, JL, Rosenberg, R, Tsuang, D et al.. Missense and loss-of-function variants at GWAS loci in familial Alzheimer's disease. Alzheimers Dement 2024; 20 (11): 7580-7594. PubMed PMID:39233587 PubMed Central PMC11567820.
  10. Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabali, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption. medRxiv 2024; : . PubMed PMID:39148832 PubMed Central PMC11326357.
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