WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Genetic and clinical risk prediction model for postoperative atrial fibrillation.

Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D,. Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at […]

Knowledge-constrained K-medoids Clustering of Regulatory Rare Alleles for Burden Tests.

Sivley RM, Fish AE, Bush WS,. Rarely occurring genetic variants are hypothesized to influence human diseases, but statistically associating these rare variants to disease is challenging due to a lack of statistical power in most feasibly sized datasets. Several statistical tests have been developed to either collapse multiple rare variants from a genomic region into […]

SecureMA: protecting participant privacy in genetic association meta-analysis.

Xie W, Kantarcioglu M, Bush WS, Crawford D, Denny JC, Heatherly R, Malin BA,. Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access […]

Recent Publications

  1. Khurshid, Z, Tong, T, Olayinka, OA, Zhu, C, Farrell, JJ, Alzheimer's Disease Sequencing Project (ADSP), Martin, ER, Bush, WS, Pericak‐Vance, M, Wang, LS et al.. Genetic variants associated with Alzheimer's disease and telomere length. Alzheimers Dement 2025; 21 (Suppl 2): . PubMed PMID:41520367 PubMed Central PMC12790854.
  2. Mustafa, Y, Mews, M, Gu, T, Gomez, L, Adams, LD, Starks, TD, Cornejo‐Olivas, M, Illanes‐Manrique, MZ, Silva‐Vergara, C, Feliciano‐Astacio, BE et al.. Peripheral Immune Composition in Alzheimer's Disease: Insights from Multi‐Ancestry RNA‐Sequencing and Cell Deconvolution. Alzheimers Dement 2025; 21 (Suppl 2): . PubMed PMID:41518049 PubMed Central PMC12789895.
  3. Khurshid, Z, Farrell, JJ, Tong, T, Zhu, C, Alzheimer's Disease Sequencing Project, Martin, ER, Bush, W, Pericak-Vance, MA, Wang, LS, Schellenberg, G et al.. Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection. J Alzheimers Dis 2025; : 13872877251405497. PubMed PMID:41428483 .
  4. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
  5. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease. bioRxiv 2025; : . PubMed PMID:41279621 PubMed Central PMC12637479.
  6. Mustafa, Y, Main, LR, Mews, M, Janve, VA, Hohman, TJ, Haines, JL, Song, YE, Griswold, AJ, Pericak-Vance, MA, Scott, WK et al.. Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study. Transl Psychiatry 2025; 15 (1): 481. PubMed PMID:41253753 PubMed Central PMC12627486.
  7. Gorski, M, Grunin, M, Herold, JM, Fröhlich, B, Behr, M, Wheeler, N, Bush, WS, Song, YE, Zhu, X, Blanton, SH et al.. Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls. Invest Ophthalmol Vis Sci 2025; 66 (13): 51. PubMed PMID:41159651 PubMed Central PMC12577769.
  8. Cukier, HN, DeRosa, BA, Coombs, LE, Tang, E, Leyva, DR, Lazzaro, AR, Gu, E, Dykxhoorn, DM, Haines, JL, Pericak-Vance, MA et al.. Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome. Stem Cell Res 2025; 89 : 103851. PubMed PMID:41086611 .
  9. Kurniansyah, N, Tasaki, S, Rehman, H, Zhu, C, Farrell, J, Sherva, R, Hauger, R, Merritt, VC, Panizzon, M, Zhang, R et al.. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv 2025; : . PubMed PMID:41040715 PubMed Central PMC12486013.
  10. Bledsoe, X, Wang, TC, Wu, Y, Archer, D, Chen, HH, Naj, A, Bush, WS, Hohman, TJ, Dumitrescu, L, Below, JE et al.. Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's Disease. medRxiv 2025; : . PubMed PMID:41001458 PubMed Central PMC12458493.
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