WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Bioinformatics challenges in genome-wide association studies (GWAS).

De R, Bush WS, Moore JH,. Genome-wide association studies (GWAS) are a powerful tool for investigators to examine the human genome to detect genetic risk factors, reveal the genetic architecture of diseases and open up new opportunities for treatment and prevention. However, despite its successes, GWAS have not been able to identify genetic loci that […]

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA,. G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received […]

Recent Publications

  1. Le Borgne, J, Gomez, L, Heikkinen, S, Amin, N, Ahmad, S, Choi, SH, Bis, J, Grenier-Boley, B, Rodriguez, OG, Kleineidam, L et al.. X-chromosome-wide association study for Alzheimer's disease. Mol Psychiatry 2024; : . PubMed PMID:39633006 .
  2. Liu, R, Qiao, X, Shi, Y, Peterson, CB, Bush, WS, Cominelli, F, Wang, M, Zhang, L. Constructing phylogenetic trees for microbiome data analysis: A mini-review. Comput Struct Biotechnol J 2024; 23 : 3859-3868. PubMed PMID:39554614 PubMed Central PMC11564040.
  3. Cruz-González, S, Gu, E, Gomez, L, Mews, M, Vance, JM, Cuccaro, ML, Cornejo-Olivas, MR, Feliciano-Astacio, BE, Byrd, GS, Haines, JL et al.. Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals. bioRxiv 2024; : . PubMed PMID:39464059 PubMed Central PMC11507840.
  4. Tong, T, Zhu, C, Farrell, JJ, Khurshid, Z, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Neuroimaging Initiative, Martin, ER, Pericak-Vance, MA, Wang, LS, Bush, WS, Schellenberg, GD et al.. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther 2024; 16 (1): 234. PubMed PMID:39444005 PubMed Central PMC11515778.
  5. Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement 2024; : . PubMed PMID:39428839 .
  6. Kuzma, A, Valladares, O, Greenfest-Allen, E, Nicaretta, H, Kirsch, M, Ren, Y, Katanic, Z, White, H, Wilk, A, Bass, L et al.. NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research. medRxiv 2024; : . PubMed PMID:39417134 PubMed Central PMC11483014.
  7. Kaur, H, Alluri, RK, Wu, K, Kalayjian, RC, Bush, WS, Palella, FJ, Koletar, SL, Hileman, CO, Erlandson, KM, Ellis, RJ et al.. Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV. Antioxidants (Basel) 2024; 13 (9): . PubMed PMID:39334701 PubMed Central PMC11429126.
  8. Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabali, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption. medRxiv 2024; : . PubMed PMID:39148832 PubMed Central PMC11326357.
  9. Cheng, PL, Wang, H, Dombroski, BA, Farrell, JJ, Horng, I, Chung, T, Tosto, G, Kunkle, BW, Bush, WS, Vardarajan, B et al.. A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD). medRxiv 2024; : . PubMed PMID:39108532 PubMed Central PMC11302603.
  10. Ray, NR, Kunkle, BW, Hamilton-Nelson, K, Kurup, JT, Rajabli, F, Qiao, M, Vardarajan, BN, Cosacak, MI, Kizil, C, Jean-Francois, M et al.. Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry. Alzheimers Dement 2024; 20 (8): 5247-5261. PubMed PMID:38958117 PubMed Central PMC11350055.
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