Dr. Emily R. Pfaff received her Masters in Information Science and her PhD in Clinical and Health Informatics, both from the University of North Carolina (UNC). Since 2011, Dr. Pfaff has served in multiple roles in the North Carolina Translational and Clinical Sciences Institute (NC TraCS), UNC's CTSA. Dr. Pfaff is currently NC TraCS Co-Director for Informatics and Data Science. She is also Associate Director of UNC Chapel Hill School of Medicine's Program on Clinical and Health Informatics. Dr. Pfaff has an academic appointment as Research Associate Professor in the Department of Medicine, Division of Endocrinology & Metabolism at UNC Chapel Hill School of Medicine. Dr. Pfaff is nationally known for her work and leadership in the National Covid Cohort Collaborative (N3C), now known as the N3C COVID Enclave. The N3C COVID Enclave is the largest data enclave of de-identified, individual-level clinical data available for COVID-19 research. Dr. Pfaff and others are piloting additional data enclaves as part of the expansion of N3C, the National Clinical Cohort Collaborative.
Recent Publications
- Mateos, MK, Ajuyah, P, Fuentes-Bolanos, N, El-Kamand, S, Barahona, P, Altekoester, AK, Mayoh, C, Holliday, H, Liu, J, Cui, L et al.. Germline analysis of an international cohort of pediatric diffuse midline glioma patients. Neuro Oncol 2025; : . PubMed PMID:40072012 .
- Mandel, HL, Shah, SN, Bailey, LC, Carton, T, Chen, Y, Esquenazi-Karonika, S, Haendel, M, Hornig, M, Kaushal, R, Oliveira, CR et al.. Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative. J Med Internet Res 2025; 27 : e59217. PubMed PMID:40053748 PubMed Central PMC11923460.
- Gessner, KH, Preisser, JS, Pfaff, E, Wang, R, Walters, K, Bradford, R, Clark, M, Ehlers, M, Nielsen, M. Predictors of new persistent opioid use after surgery in adults. Anesthesiol Perioper Sci 2025; 3 (1): 2. PubMed PMID:40051586 PubMed Central PMC11880104.
- Martin, B, DeWitt, PE, Russell, S, Haendel, M, Sanchez-Pinto, N, Albers, DJ, Jhaveri, RR, Moffitt, R, Bennett, TD, N3C Consortium et al.. The Recent Increase in Invasive Bacterial Infections: A Report From the National COVID Cohort Collaborative. Pediatr Infect Dis J 2025; 44 (3): 217-227. PubMed PMID:39951364 PubMed Central PMC11812670.
- Mandel, H, Yoo, YJ, Allen, AJ, Abedian, S, Verzani, Z, Karlson, EW, Kleinman, LC, Mudumbi, PC, Oliveira, CR, Muszynski, JA et al.. Long-COVID incidence proportion in adults and children between 2020 and 2024. Clin Infect Dis 2025; : . PubMed PMID:39907495 .
- Soff, S, Yoo, YJ, Bramante, C, Reusch, JEB, Huling, JD, Hall, MA, Brannock, D, Sturmer, T, Butzin-Dozier, Z, Wong, R et al.. Association of glycemic control with Long COVID in patients with type 2 diabetes: findings from the National COVID Cohort Collaborative (N3C). BMJ Open Diabetes Res Care 2025; 13 (1): . PubMed PMID:39904520 PubMed Central PMC11795369.
- Pfaff, E, Schramm, K, Blattner-Johnson, M, Jones, BC, Stark, S, Balasubramanian, GP, Previti, C, Autry, RJ, Fiesel, P, Sahm, F et al.. Pediatric spinal high-grade glioma in the pediatric precision oncology registry INFORM: Identification of potential therapeutic targets. Neurooncol Adv 2025; 7 (1): vdae185. PubMed PMID:39896072 PubMed Central PMC11783565.
- Bhatia, A, Preiss, AJ, Xiao, X, Brannock, MD, Alexander, GC, Chew, RF, Davis, H, Fitzgerald, M, Hill, E, Kelly, EP et al.. Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C. PLoS Med 2025; 22 (1): e1004493. PubMed PMID:39823513 PubMed Central PMC11790232.
- Hung, P, Yu, J, Harrison, SE, Liu, J, Promiti, A, Odahowski, C, Campbell, BA, Chatterjee, A, Boghoossian, NS, Cai, B et al.. Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US. JAMA Netw Open 2024; 7 (12): e2449243. PubMed PMID:39641928 PubMed Central PMC11624583.
- Lamoureux, AA, Fisher, MJ, Lemelle, L, Pfaff, E, Amir-Yazdani, P, Kramm, C, De Wilde, B, Kazanowska, B, Hutter, C, Pfister, SM et al.. Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions. Clin Cancer Res 2025; 31 (3): 561-572. PubMed PMID:39625867 PubMed Central PMC11788648.
