Dr. Fred Schumacher is Associate Professor in the Department of Population and Quantitative Health Sciences and Faculty in the Cleveland Institute for Computational Biology, both at Case Western Reserve University. Dr. Schumacher is also Co-Leader of the Cancer Prevention Control & Population Research Program as part of the Case Comprehensive Cancer Center. His primary research focus is on cancer, particularly prostate cancer. As an investigator and leader in several major international consortium, Dr. Schumacher has
- Identified multiple novel genomic regions associated with prostate, testicular and breast cancer, representing discoveries based on incorporating genome-wide association studies (GWAS) with cancer epidemiology
- Expanded the use of GWAS through combined studies of varying design, providing the power to evaluate candidate gene pathways, incorporate related biomarkers, and assess cancer sub-types
- Explored the potential biological overlap of complex traits and conditions (such as diabetes) with cancer, providing a better understanding of the cancer initiation process and highlighting several areas for potential disease risk reduction.
- Developed and implemented polygenic risk scores to improve screening modalities and treatment paradigms
Recent Publications
- Srinivasan, S, Kryza, T, Bock, N, Tse, BWC, Sokolowski, KA, Janaththani, P, Fernando, A, Moya, L, Stephens, C, Dong, Y et al.. A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer. Nat Commun 2024; 15 (1): 9587. PubMed PMID:39505858 PubMed Central PMC11541583.
- Wu, Y, Miller, ME, Gilmore, HL, Thompson, CL, Schumacher, FR. Epigenetic aging differentially impacts breast cancer risk by self-reported race. PLoS One 2024; 19 (10): e0308174. PubMed PMID:39446903 PubMed Central PMC11500918.
- Wilfred Wu, CH, Patel, I, Lovrenert, K, Eisner, B, Meeks, N, Chun-Hui Tsai, A, Baum, M, Berry, G, Schumacher, FR. The role of double heterozygotes of SLC3A1 and SLC7A9 in the prevalence of cystine stones. Genet Med 2024; 27 (1): 101281. PubMed PMID:39315525 .
- Cui, Z, Schumacher, FR. Small-group originating model: Optimized individual-level GWAS simulation featured by SLiM and using open-access data. Comput Biol Chem 2024; 112 : 108147. PubMed PMID:39033733 .
- Iyer, HS, Stone, BV, Roscoe, C, Hsieh, MC, Stroup, AM, Wiggins, CL, Schumacher, FR, Gomez, SL, Rebbeck, TR, Trinh, QD et al.. Access to Prostate-Specific Antigen Testing and Mortality Among Men With Prostate Cancer. JAMA Netw Open 2024; 7 (6): e2414582. PubMed PMID:38833252 PubMed Central PMC11151156.
- Vince, RA Jr, Sun, H, Singhal, U, Schumacher, FR, Trapl, E, Rose, J, Cullen, J, Zaorsky, N, Shoag, J, Hartman, H et al.. Assessing the Clinical Utility of Published Prostate Cancer Polygenic Risk Scores in a Large Biobank Data Set. Eur Urol Oncol 2024; : . PubMed PMID:38734542 .
- Meng, G, Pan, Y, Tang, W, Zhang, L, Cui, Y, Schumacher, FR, Wang, M, Wang, R, He, S, Krischer, J et al.. imply: improving cell-type deconvolution accuracy using personalized reference profiles. Genome Med 2024; 16 (1): 65. PubMed PMID:38685057 PubMed Central PMC11057104.
- Chen, Z, Guo, X, Tao, R, Huyghe, JR, Law, PJ, Fernandez-Rozadilla, C, Ping, J, Jia, G, Long, J, Li, C et al.. Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes. Nat Commun 2024; 15 (1): 3557. PubMed PMID:38670944 PubMed Central PMC11053150.
- Wu, CW, Huang, YR, Bodner, D, Schumacher, FR, Baum, M, Hildebrandt, F. The evolving landscape of monogenic nephrolithiasis and therapeutic innovations. Nat Rev Urol 2024; 21 (9): 513-514. PubMed PMID:38632353 .
- Yarmolinsky, J, Robinson, JW, Mariosa, D, Karhunen, V, Huang, J, Dimou, N, Murphy, N, Burrows, K, Bouras, E, Smith-Byrne, K et al.. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis. EBioMedicine 2024; 100 : 104991. PubMed PMID:38301482 PubMed Central PMC10844944.