Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, BS, Trittschuh, EH, Mez, J, Farrer, LA, Gifford, KA et al.. Evaluating the association of APOE genotype and cognitive resilience in SuperAgers. medRxiv 2025; : . PubMed PMID:39830268 PubMed Central PMC11741496.
  2. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Examination of MGMT as a risk gene for dementia in the Amish. Alzheimers Dement 2025; 21 (1): e14356. PubMed PMID:39711484 PubMed Central PMC11782184.
  3. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset. medRxiv 2024; : . PubMed PMID:39677464 PubMed Central PMC11643159.
  4. Gorman, BR, Voloudakis, G, Igo, RP Jr, Kinzy, T, Halladay, CW, Bigdeli, TB, Zeng, B, Venkatesh, S, Cooke Bailey, JN, Crawford, DC et al.. Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nat Genet 2024; 56 (12): 2659-2671. PubMed PMID:39623103 .
  5. Bertholim-Nasciben, L, Nuytemans, K, Van Booven, D, Rajabli, F, Moura, S, Ramirez, AM, Dykxhoorn, DM, Wang, L, Scott, WK, Davis, DA et al.. African origin haplotype protective for Alzheimer's disease in APOEε4 carriers: exploring potential mechanisms. bioRxiv 2024; : . PubMed PMID:39484566 PubMed Central PMC11527192.
  6. Cruz-González, S, Gu, E, Gomez, L, Mews, M, Vance, JM, Cuccaro, ML, Cornejo-Olivas, MR, Feliciano-Astacio, BE, Byrd, GS, Haines, JL et al.. Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals. bioRxiv 2024; : . PubMed PMID:39464059 PubMed Central PMC11507840.
  7. Tong, T, Zhu, C, Farrell, JJ, Khurshid, Z, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Neuroimaging Initiative, Martin, ER, Pericak-Vance, MA, Wang, LS, Bush, WS, Schellenberg, GD et al.. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther 2024; 16 (1): 234. PubMed PMID:39444005 PubMed Central PMC11515778.
  8. Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement 2024; 20 (12): 8470-8483. PubMed PMID:39428839 PubMed Central PMC11667527.
  9. Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2024; 56 (11): 2407-2421. PubMed PMID:39379761 PubMed Central PMC11549054.
  10. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2. Alzheimers Dement 2024; 20 (11): 7453-7464. PubMed PMID:39376159 PubMed Central PMC11567819.
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The Haines Lab Website

Curriculum vitae

thumbnail of Haines CV 2015-07-14