As of 2018, I have attended a grand total of six Pacific Symposium on Biocomputing (PSB) meetings, all held on the Big Island of Hawaii. This figure is not impressive compared with colleagues and PSB early adopters like Drs. Marylyn Ritchie and Will Bush (Figure 1). Nor is it impressive compared with the founders of […]
The consensus is clear: there is a need for diversity in precision medicine research. Most of the current dialogue on diversity centers on study populations. Genome-wide association studies (GWAS), which began in earnest in 2007 with publication of the landmark Wellcome Trust Case Control Consortium study of seven common diseases (PMIC2719288) and a trio of […]
The Translational Bioinformatics Conference (TBC) was established in 2011 as a partnership between Asian and US investigators with the goal of bringing together scientists with the diverse expertise that contribute to the new and growing field of translational bioinformatics. The first conference, led by Dr. Ju Han Kim, Professor and Chair of the Division of […]
We have now organized two symposia focusing on big data and precision medicine topics with a third one in the works focusing on measuring exposures. In an effort to sustain the dialog initiated by each of these events, we are hosting a blog on this website. This blog will feature short opinion pieces and articles […]
We are at the time of the year when I like to reflect back on the Pacific Symposium on Biocomputing (PSB). It’s February, which means the snow is still blowing here at CWRU, and the temperatures are not inspiring the use of swimwear (Figure 1). The most recent PSB meeting was January 4-8, 2016, on […]
Who: Dana C. Crawford, PhD What: Kathryn Morgan and The Red Shoes Where: Playhouse Square, 1501 Euclid Ave #200, Cleveland, OH 44115 Much like my manuscripts, grants, and other official work duties, I find myself perpetually late in fulfilling my blog duties. Consequently, I write about events and dining experiences that took place months ago […]
Calcineurin-inhibitors CI are immunosuppressive agents prescribed to patients after solid organ transplant to prevent rejection. Although these drugs have been transformative for allograft survival, long-term use is complicated by side effects including nephrotoxicity. Given the narrow therapeutic index of CI, therapeutic drug monitoring is used to prevent acute rejection from underdosing and acute toxicity from […]
Oetjens M, Bush WS, Birdwell KA, Dilks HH, Bowton EA, Denny JC, Wilke RA, Roden DM, Crawford DC,. Calcineurin-inhibitors CI are immunosuppressive agents prescribed to patients after solid organ transplant to prevent rejection. Although these drugs have been transformative for allograft survival, long-term use is complicated by side effects including nephrotoxicity. Given the narrow therapeutic […]
Genome-wide association studies (GWAS) have identified hundreds of genomic regions associated with common human disease and quantitative traits. A major research avenue for mature genotype-phenotype associations is the identification of the true risk or functional variant for downstream molecular studies or personalized medicine applications. As part of the Population Architecture using Genomics and Epidemiology (PAGE) […]
Crawford DC, Goodloe R, Brown-Gentry K, Wilson S, Roberson J, Gillani NB, Ritchie MD, Dilks HH, Bush WS,. Genome-wide association studies (GWAS) have identified hundreds of genomic regions associated with common human disease and quantitative traits. A major research avenue for mature genotype-phenotype associations is the identification of the true risk or functional variant for […]
Most genotype-phenotype studies have historically lacked population diversity, impacting the generalizability of findings and thereby limiting the ability to equitably implement precision medicine. This well-documented problem has generated much interest in the ascertainment of new cohorts with an emphasis on multiple dimensions of diversity, including race/ethnicity, gender, age, socioeconomic status, disability, and geography. The most […]
Most genotype-phenotype studies have historically lacked population diversity, impacting the generalizability of findings and thereby limiting the ability to equitably implement precision medicine. This well-documented problem has generated much interest in the ascertainment of new cohorts with an emphasis on multiple dimensions of diversity, including race/ethnicity, gender, age, socioeconomic status, disability, and geography. The most […]